Genetic mapping of complex traits by minimizing integrated square errors
نویسندگان
چکیده
منابع مشابه
Mapping the genetic architecture of complex traits in experimental populations
SUMMARY Understanding how interactions among set of genes affect diverse phenotypes is having a greater impact on biomedical research, agriculture and evolutionary biology. Mapping and characterizing the isolated effects of single quantitative trait locus (QTL) is a first step, but we also need to assemble networks of QTLs and define non-additive interactions (epistasis) together with a host of...
متن کاملOrdered subset analysis in genetic linkage mapping of complex traits.
Etiologic heterogeneity is a fundamental feature of complex disease etiology; genetic linkage analysis methods to map genes for complex traits that acknowledge the presence of genetic heterogeneity are likely to have greater power to identify subtle changes in complex biologic systems. We investigate the use of trait-related covariates to examine evidence for linkage in the presence of heteroge...
متن کاملGenetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae
Signaling pathways enable cells to sense and respond to their environment. Many cellular signaling strategies are conserved from fungi to humans, yet their activity and phenotypic consequences can vary extensively among individuals within a species. A systematic assessment of the impact of naturally occurring genetic variation on signaling pathways remains to be conducted. In S. cerevisiae, bot...
متن کاملThe Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses.
We use computer simulations to investigate the amount of genetic variation for complex traits that can be revealed by single-SNP genome-wide association studies (GWAS) or regional heritability mapping (RHM) analyses based on full genome sequence data or SNP chips. We model a large population subject to mutation, recombination, selection, and drift, assuming a pleiotropic model of mutations samp...
متن کاملGenetic Dissection of Complex Traits: From Functional Mapping to Systems Mapping
Many statistical tools have been developed to map and study the genetic architecture of complex phenotypes important to agriculture, biology, and biomedicine [1-9]. Thanks to recent advances in sequencing and genotyping technologies, DNA-based marker data crucial for genetic mapping can be generated almost with no limit. A new challenge that faces methodological development is how to dissect a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Genetics
سال: 2012
ISSN: 1471-2156
DOI: 10.1186/1471-2156-13-20